Dermasol Cream (Clobetasol Propionate 0.05%)belongs to a group of medicines called steroids. It is used to treat various skin conditions such as dermatitis, eczema, and allergies.
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Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Due to a lack of sufficient safety data, Dermasol 0.05% Cream is not recommended for use during pregnancy. Hence, consult your doctor if you are pregnant.
It is not known if Dermasol 0.05% Cream passes into breastmilk. Hence, if you are breastfeeding, consult your doctor to understand the potential risks and benefits before using this medicine. If your doctor has recommended this medicine, avoid applying it to the breast area to prevent accidental ingestion by your baby.
No interaction found/established
No interaction found/established
No interaction found/established
Dermasol 0.05% Cream works with the help of corticosteroids to calm down irritated skin. These corticosteroids help reduce inflammation, redness, and itching of the skin. When you apply clobetasol propionate cream on your skin, it shrinks the blood vessels. This in turn stops the release of irritating substances and decreases the production of certain cells that cause inflammation. This helps to soothe the skin and promotes skin healing.
Clobetasol propionate cream may cause the following side effects:
Common side effects:
Serious side effects:
It is important to seek immediate medical attention if you experience any of the serious side effects mentioned above.
In children, the use of clobetasol propionate cream may potentially lead to reduced growth and delayed weight gain. It is recommended to consult your child's doctor before applying the medication to your child's skin to discuss the potential risks and benefits.
If you have any concerns or notice any unusual symptoms while using clobetasol propionate cream, it is advisable to contact your doctor for further evaluation and guidance.
Clobetasol propionate is prescribed to treat the following dermatoses in adults, the elderly, and children over the age of one year:
Clobetasol is a very potent corticosteroid that is used for short-term treatment of various inflammatory skin conditions. Corticosteroids like clobetasol work by reducing inflammation through multiple mechanisms. Here are some of the ways in which corticosteroids exert their anti-inflammatory effects:
Stabilizing leukocyte lysosomal membranes: Corticosteroids stabilize the membranes of certain immune cells called leukocytes, preventing the release of destructive acid hydrolases from these cells.
Inhibiting macrophage accumulation: Corticosteroids reduce the accumulation of macrophages, a type of immune cell, in inflamed areas of the skin.
Reducing leukocyte adhesion: Corticosteroids decrease the adhesion of leukocytes to the endothelium (the inner lining of blood vessels), thereby reducing their migration to inflamed areas.
Decreasing capillary wall permeability and edema formation: Corticosteroids help to reduce the permeability of capillary walls, which helps in reducing the leakage of fluid into tissues and the formation of edema (swelling).
Decreasing complement components: A complement is a group of proteins involved in immune responses. Corticosteroids can reduce the levels and activity of complement components, which contribute to inflammation.
Antagonizing histamine activity and release of kinin: Corticosteroids counteract the activity of histamine, a chemical involved in allergic reactions and inflammation. They also reduce the release of kinin, another group of chemicals that promote inflammation.
Reducing fibroblast proliferation and collagen deposition: Corticosteroids inhibit the proliferation of fibroblasts, and cells involved in tissue repair, and reduce the deposition of collagen, which helps in preventing excessive scar tissue formation.
The adult dose recommendations for clobetasol in various dermatoses are as follows:
For children under 12 years of age, the safety and efficacy of clobetasol have not been established. Therefore, it is not recommended for use in this age group.
For children 12 years and older, the dosing recommendations are the same as for adults, following the guidelines mentioned above for corticosteroid-responsive dermatoses, scalp psoriasis shampoo, and moderate to severe plaque-type psoriasis cream/lotion.
It is important to follow the instructions provided by your healthcare provider and not exceed the recommended dosage. If you have any questions or concerns about the appropriate dosage for your specific condition, consult with your healthcare professional.
Co-administration of medications that inhibit the enzyme CYP3A4, such as ritonavir and itraconazole, can inhibit the metabolism of corticosteroids. This inhibition can lead to increased systemic exposure to corticosteroids, potentially resulting in an increased risk of systemic side effects. It is important to be cautious when using corticosteroids in combination with such medications, and close monitoring by a healthcare professional is recommended to ensure the appropriate and safe use of these medications together. If you are taking any medications that inhibit CYP3A4, it is important to inform your healthcare provider before using corticosteroids. They can provide guidance on the potential interactions and adjust the dosages if necessary.
Dermasol 0.05% Cream is not recommended for use in children under 12 years of age. It is primarily used for long-term treatment of ulcerative conditions, rosacea, and pruritus. However, it is contraindicated in certain cases, including:
Safety data on the use of clobetasol in pregnant women is not available. However, published data suggest a significantly increased risk of low birth weight when using potent or very potent topical corticosteroids exceeding 300 grams during pregnancy. Pregnant women should be informed about the potential risk to the fetus, and clobetasol should be used on the smallest area of skin and for the shortest duration possible.
Animal reproduction studies have shown increased malformations, such as cleft palate and skeletal abnormalities when clobetasol was administered subcutaneously to pregnant mice and rabbits.
Regarding lactation, there is no information available on the presence of clobetasol in breast milk or its effects on the breastfed infant or milk production. Systemically administered corticosteroids can appear in human milk and may have adverse effects on the breastfed infant, such as growth suppression and interference with endogenous corticosteroid production. It is unknown whether topical administration of clobetasol can result in sufficient systemic absorption to detectable quantities in human milk.
To minimize potential exposure to the breastfed infant, clobetasol should be used on the smallest area of skin and for the shortest duration possible while breastfeeding. Breastfeeding women should be advised to avoid applying clobetasol directly to the nipple and areola to prevent direct exposure to the infant. It is recommended to consult with a healthcare professional for individualized guidance on the use of clobetasol during pregnancy and lactation.
Keep the temperature below 30°C and away from light and moisture. Do not allow yourself to become frozen. Keep out of children's reach.
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